INCFinder

GenBank ID	CP144511.1
Plasmid name	pJNP888-1
Classification	C2
Length	78 971 bp
GC content	51%
Organism	Klebsiella pneumoniae strain JNP888
Curation	Manually annotated

Large parts of the IncC backbone including orf1847 is missing. The 5' part of RHS2 (1-3811 bp of the gene) is deleted.

Gene name	Length	Location	Length of alignment	Identity (%)	Coverage (%)
repA	1101	68442 - 69542 (+)	1101	100	100
I1	428	10299 - 10726 (+)	428	100	100
I2	462	34115 - 34576 (+)	462	100	100
RHS2	452	44290 - 44741 (+)	452	100	11

Type match	Model name	Model type	Location	E-value	Identity
Perfect	FosA3	protein homolog model	22182 - 22598(-)	1.60476e-102	100 %
fosfomycin thiol transferase AMR Gene Family Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin. fosfomycin Drug Class Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. antibiotic inactivation Resistance Mechanism Enzymatic inactivation of antibiotic to confer drug resistance.