INCFinder

GenBank ID	CP144507.1
Plasmid name	pJNP887-1
Classification	C2
Length	122 031 bp
GC content	51%
Organism	Klebsiella pneumoniae strain JNP887
Curation	Automatic annotation

Gene name	Length	Location	Length of alignment	Identity (%)	Coverage (%)
repA	1101	96545 - 97645 (-)	1101	100	100
ORF1847	5544	29386 - 34929 (-)	5544	100	100
I1	428	76391 - 76818 (-)	428	100	100
I2	462	52542 - 53003 (-)	462	100	100
RHS2	452	121347 - 121798 (-)	452	100	11

Type match	Model name	Model type	Location	E-value	Identity
Perfect	FosA3	protein homolog model	64519 - 64935(+)	1.60476e-102	100 %
fosfomycin thiol transferase AMR Gene Family Catalyzes the addition of a thiol group from a nucleophilic molecule to fosfomycin. fosfomycin Drug Class Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. antibiotic inactivation Resistance Mechanism Enzymatic inactivation of antibiotic to confer drug resistance.