INCFinder

GenBank ID	CP130195.1
Plasmid name	p2014C09-015-50k
Classification	C2
Length	50 502 bp
GC content	51%
Organism	Klebsiella pneumoniae strain 2014C09-015
Curation	Manually annotated

Plasmid map

Notes

Most of the IncC backbone including orf1847/1832, RHS and the site of I2 insertion is missing. The presence of I1 insertion and the higher overall homology to pR55 (99.99%, 81% coverage) than to pR148 (99.84%, 80% coverage) suggest that the plasmid is an IncC2 derivative.

Characteristic genes

Gene name	Length	Location	Length of alignment	Identity (%)	Coverage (%)	E-value
repA	1101	9588 - 10688 (-)	1101	100	100	0
I1	428	39401 - 39828 (-)	428	100	100	0

Antimicrobial resistance genes

Type match	Model name	Model type	Location	E-value	Identity
Perfect	APH(3')-Ia	protein homolog model	26630 - 27445(+)	0	100 %
APH(3') AMR Gene Family Phosphorylation of 2-deoxystreptamine aminoglycosides on the hydroxyl group at position 3' neomycin Antibiotic Neomycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Neomycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. ribostamycin Antibiotic Ribostamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Ribostamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. kanamycin A Antibiotic Kanamycin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Kanamycin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. G418 Antibiotic A gentamicin class aminoglycoside antibiotic often used in mammalian cell culture work as a selectable marker for the neo cassette (APH3'). paromomycin Antibiotic An aminoglycoside antibiotic used for the treatment of parasitic infections. It is similar to neomycin sharing a similar spectrum of activity, but its hydroxyl group at the 6'-position instead of an amino group makes it resistant to AAC(6') modifying enzymes. lividomycin A Antibiotic Lividomycin A is a pentasaccharide antibiotic which interferes with bacterial protein synthesis. lividomycin B Antibiotic Lividomycin B is a derivative of lividomycin A with a removed mannose group (demannosyllividomycin A). Livodomycins interfere with bacterial protein synthesis. aminoglycoside antibiotic Drug Class Aminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth. antibiotic inactivation Resistance Mechanism Enzymatic inactivation of antibiotic to confer drug resistance.

Plasmid genes

AMR genes

Plasmid map

Notes

Characteristic genes

Antimicrobial resistance genes