AMR Gene Family
CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins.
Drug Class
Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases.
Resistance Mechanism
Enzymatic inactivation of antibiotic to confer drug resistance.