INCFinder

GenBank ID	CP016036.1
Plasmid name	pC06114_2
Classification	C1
Length	92 009 bp
GC content	49%
Organism	Escherichia coli isolate Co6114
Curation	Manually annotated

Plasmid map

Notes

An IS26-mediated deletion removed the plasmid backbone from the 3' half of orf1832 (from 2772 bp of the gene) to the orf located downstream of RHS1, thus RHS1 is missing.

Characteristic genes

Gene name	Length	Location	Length of alignment	Identity (%)	Coverage (%)	E-value
repA	1101	33589 - 34689 (+)	1101	99	100	0
ORF1832	2771	89112 - 91882 (+)	2771	100	50	0

Antimicrobial resistance genes

Type match	Model name	Model type	Location	E-value	Identity
Perfect	CMY-2	protein homolog model	38866 - 40011(-)	0	100 %
CMY beta-lactamase AMR Gene Family CMY beta-lactamases are plasmid-mediated class C beta-lactamases that encodes for resistance to cephamycins. cefoxitin Antibiotic Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases. ceftazidime Antibiotic Ceftazidime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram-positive and Gram-negative bacteria. Unlike most third-generation agents, it is active against Pseudomonas aeruginosa, however it has weaker activity against Gram-positive microorganisms and is not used for such infections. cephalosporin Drug Class Cephalosporins are a class of beta-lactam antibiotics, containing the beta-lactam ring fused with a dihydrothiazolidine ring. Together with cephamycins they belong to a sub-group called cephems. Cephalosporin are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. cephamycin Drug Class Cephamycins are a group of beta-lactam antibiotics, very similar to cephalosporins. Together with cephalosporins, they form a sub-group of antibiotics known as cephems. Cephamycins are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The 7-alpha-methoxy group increases resistance to beta-lactamases. antibiotic inactivation Resistance Mechanism Enzymatic inactivation of antibiotic to confer drug resistance.